Spiriva Side Effects. Severity: Major. If any of the following side effects occur while taking tiotropium, check with your doctor immediately:
Arm, back, or jaw pain
chest pain or discomfort
chest tightness or heaviness
fast or irregular heartbeat
nausea
shortness of breath
sweating
cough
difficulty with swallowing
dizziness
hives, itching, or skin rash
painful blisters on the trunk of body