Clonidine Side Effects, Upsides, Downsides & How it Works

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Clonidine Side Effects. Severity: Major. You should check with your doctor immediately if any of these side effects occur when taking clonidine:

  • Mental depression
  • swelling of the feet and lower legs
  • anxiety
  • blistering, burning, crusting, dryness, or flaking of the skin
  • chest pain or discomfort
  • confusion as to time, place, or person
  • decreased urine output
  • dilated neck veins
  • drowsiness
  • dry mouth
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