Zanaflex Side Effects, Important Information, Before Taking & More

Zanaflex (tizanidine) is a prescribed medicinal drug that is used for treating spasticity, a medical ailment in which muscles tense up, cramp or experience muscle spasms usually resulting because of medical conditions such as an injured spine or multiple sclerosis. Zanaflex is usually available under the generic brand name tizanidine. It works by blocking nerve impulses, so the brain can’t sense pain being signaled from the muscles. Tizanidine is found in 2mg white circular oral tablets, 2mg blue, and 4mg white, and blue colored oral capsules.


It is essential to follow your doctor’s orders while taking Zanaflex; consumption of a tablet and the capsule will have different effects on the body, one might be more effective than the other. Make sure that the way you take your medicine is constant, e.g., if you’re taking Zanaflex with a meal or you sprinkle a capsule on your food or take it without food, then always take it that way otherwise the efficiency of the drug can decrease, or the side effects can increase. Leave a gap of 6-8 hours before taking the next dose; the maximum recommended amount in 24-hours is only 3 doses. Do not exceed that.


Side Effects

While using Zanaflex, be wary of the adverse effects it may cause; if the below mentioned negative indications are manifested or experienced, then contact your doctor immediately.

Common unwanted symptoms may include:

  • Dizziness
  • Drowsiness
  • Lack of coordination and balance
  • Unexplained exhaustion
  • Lightheadedness
  • Blurred vision
  • Dry mouth

These signs may also occur:

  • Flu-like symptoms
  • Coughing
  • Sore throat
  • Sneezing


The prevalent side effects that Zanaflex causes are:

  • Burning sensation while urinating
  • Pain in the chest
  • Nausea or vomiting
  • Feeling weak
  • Fever or chills

Zanaflex is also known to cause:

  • Mood problems
  • Anxiety
  • Hallucinations
  • Loss of consciousness
  • Jaundice
  • Dark urine
  • Abdominal pain
  • Vomiting

You may experience withdrawal symptoms too like anxiety when you leave this medication.


How it works

Tizanidine is a centrally acting α₂ adrenergic agonist that functions by temporarily relieving muscle tone resulting from spasticity; it simply works by reducing rapid firing of neural impulses in the brain, so it cannot sense pain signals arising from the muscles.



Before taking Zanaflex, ensure with utmost caution that all possible trouble causing variables are dealt with. You must follow certain precautions when starting its course:

Zanaflex is a relaxant and is known to have sedative effects on the body. Refrain from activities that require your motor vigilance such as driving or operating machinery.

Antidepressants like Luvox and an antibiotic medication like Crispo are notorious for reacting with Zanaflex. If these drugs are being consumed in combination, then side effects in the body can be enhanced that can prove potentially damaging. Narcotics like marijuana and alcohol are by nature sedating; if Zanaflex is added to this tranquil mix, then the side effects such as drowsiness and dizziness will escalate. Always inform your doctor if you’re currently on any specific type of drug so he can better understand how to treat you.


Drugs do have the potential for interfering with past or current diseases which you may be having, so it is mandatory for you to notify your medical advisor if you’re suffering from any problematic ailment. Zanaflex reduces liver functioning; before taking it, inform your doctor if you have a history of liver disease, kidney problems, or low blood pressure.

Neither are there any proper researches indicating whether Zanaflex has any damaging effect on the fetus; nor is there any evidence depicting that it passes into breast milk. Women in such circumstances should always discuss the major risks and benefits of using this medication to prevent any bad side effects that can prove harmful to the infant’s health.