Viibryd (Vilazodone) Side Effects, Important Info, Before Taking & How to Use

Vilazodone merchandised as Viibryd, is a serotonergic antidepressant. According to multiple tests carried out on its mode of action and effectiveness, Vilazodone evokes an antidepressant response just after a week of beginning treatment.


Many studies were unable to determine and prove if the drug offered more advantages compared to other antidepressants. The commonly recommended target dosage for the drug is 20 mg to 40 mg taken orally once daily with food to achieve the targeted results and dosage. If a patient mistakenly misses a dose, it should be taken immediately upon remembrance. If the patient remembers around a time where it’s already time for the next dose, it is recommended to skip the missed one and move to the next one. Two doses should not be taken at one time because that can have adverse effects.


Side Effects:

Minor Side Effects:

Upon exhibiting any of the following allergic reactions, immediately rush to the ER

  • Skin rash
  • Hives
  • Difficulty breathing
  • Swelling of your face, lips, tongue, or throat

Report any new or worsening symptoms to your doctor, such as:

  • Anxiety
  • Panic attacks
  • Hyperactivity (mentally or physically)
  • Abnormal dreams/sleep paralysis
  • Headache
  • Feeling impulsive, irritable, agitated, hostile, aggressive, or restless
  • Mood or behavior changes
  • Depressed or suicidal thoughts
  • Trouble sleeping (insomnia)
  • Diarrhea


Serious Side Effects:

Stop taking vilazodone and call your healthcare practitioner at once if you develop any of the serious side effects listed below:

  • Very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, overactive reflexes, feeling like you might pass out
  • Extreme thirst with headache, nausea, vomiting, weakness, trouble concentrating, memory problems, confusion, fainting, seizure, shallow breathing or breathing that stops
  • Agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, fainting
  • Seizures (convulsions)
  • Easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), blood in your urine or stools, purple or red pinpoint spots under your skin
  • Racing thoughts, unusual risk-taking behavior, decreased inhibitions, feelings of extreme happiness or sadness


How to use it?

Take this medication as suggested by the doctor; usually once daily at regular times. The dosage is determined by one’s medical condition, response to treatment, and other medications one may be taking.

Be sure to let your doctor and pharmacist know about any additional drugs you are administering (including prescription drugs, nonprescription drugs, and herbal products). To reduce the risk of side effects developing, the doctor may start the medication at a lower dose and gradually increase your dose over time.

Be diligent in following the doctor’s instructions. Do not take more or less than the prescribed amount or take it more often than prescribed as it may lead to overdose or other unnecessary complications. Your condition won’t improve any faster by taking more doses, and the risk of side effects will increase substantially.


Regular use of the medication will result in optimal results and effectiveness. To prevent the chances of forgetting, take it at the same time every day.

This medication may cause withdrawal symptoms, especially if it has been used regularly for a long time or in high doses and stopped abruptly. In such cases, withdrawal symptoms (like headaches, seizures, tiredness, “shock-like” feelings, mood swings, sleep changes, ringing in the ears, numbness/tingling) may occur if you suddenly stop the use of this medication.

To minimize or prevent withdrawal reactions, your doctor may reduce your dose gradually over time. Consult your doctor for details and report withdrawal reactions right away.

Tell your doctor if your condition persists or worsens.



Older adults may be more susceptible and sensitive to the side effects of this drug. They are more likely to develop a salt imbalance (hyponatremia), especially if they are also taking “water pills” (diuretics) in combination with this medication.

Salt imbalance can increase the risk of collapsing which can lead to fatal injuries. During pregnancy, this medication should be used only under dire and unavoidable cases. It may potentially harm an unborn baby.

Also, babies born to mothers who have used this drug during the last 3 months of pregnancy may rarely exhibit withdrawal symptoms such as difficulties in breathing or feeding, seizures, stiffness in muscles, or ceaseless crying. Upon noticing these symptoms in your newborn, immediately tell your doctor.

Since untreated mental/mood problems (such as depression or anxiety disorders) can be are life-threatening diseases, do not cease taking this medication unless directed by your doctor.