Glyburide Side Effects. Severity: Major. You should check with your doctor immediately if any of these side effects occur when taking glyburide:
- Difficulty with swallowing
- dizziness
- fast heartbeat
- hives
- itching
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- shortness of breath
- skin rash
- tightness in the chest
- unusual tiredness or weakness