Fenofibrate Side Effects, Important Info, How to Use & More

Fenofibrate is a prescribed medicinal drug used for the reduction of high triglyceride and high cholesterol levels in the blood. It belongs to the classification of drugs called antilipemic and fibric acid. It is a fibrate derivative whose main function is to decrease lipids, but along with that it also serves to eliminate bad cholesterol levels (LDL) and boost up good cholesterol levels (HDL) in the blood.


Fenofibrate is packaged under numerous brand names, i.e., Antara, Fenoglide, Lipofen, Lofibra, TriCor, and Triglide. It is available in the form of oral pills/tablets, with dosages including 40mg, 54mg, 120mg, and 160 mg. Capsules are also available in 50mg.


Side Effects

Consumption of Fenofibrate can sometimes lead to many damaging side effects. If any of the below mentioned negative symptoms are manifested in your body, then get medical help immediately.

The most recurrent and minor side effects include stomach pain, back pain, headache, or, runny or stuffy nose.

Fenofibrate is rarely known to cause diseases like gallstones and liver problems. The chance of these ailments is incredibly insignificant.



Seriously health damaging negative effects include severe stomach/abdominal pain, persistent nausea/vomiting, and yellowing eyes or skin (jaundice).

Fenofibrate can also weaken the muscles, making them tender. It can also cause weakness, kidney problems, change in color and amount of urine, and muscle pain, etc.

Also, if you experience chest pain or swelling specifically in the legs or redness, etc., rush to the emergency room. Similarly, consult a doctor if you experience easy bruising and bleeding, and cold-like symptoms such as fever, sore throat, and coughing.


Important Information

Starting this medication in a patient not only requires just merely consuming the tablet itself but also an adequate lipid-lowering diet, a moderate amount of physical activity, and a healthy body weight are also essential requirements for cholesterol treatment. The diet must be followed strictly while the patient is on this medication, routinely exercise needs to be executed, and a good BMI weight needs to be maintained. Usually, 2 months of therapy are enough for patients; if there are no improved results in this time span, then the patient is taken off this therapy.


How to Use?

Take fenofibrate as per your doctor’s orders; do not self-adjust the dosage and take the pill orally with a glass of water. Since there are several different brands for fenofibrate, their dosage might be prescribed differently as compared to one another. Do not stop taking the dose even if you feel better; complete the entire course.


How it works?

Fenofibrate simply catalyzes the process of fat breakdown in the body. It also eliminates cholesterol that builds up in between the blood vessels and clogs them, leading to stroke and heart attack. The fibrate compound in the medicine reduces the production of VLDL in the liver that carries triglyceride all around the blood. It also speeds up the removal of triglycerides from the body.



Medical studies have shown evidence that fenofibrate, in fact, does possess the potential of causing damage to the fetus. It is best to refrain from this drug unless of course necessary. Have a formal discussion about the pros and cons of using fenofibrate during pregnancy.

There is no real evidence indicating whether fenofibrate dissolves into breastmilk. Thus, the best way to ensure safety is to ask your doctor’s opinion in this situation and then consider using the drug.

Inform your medical advisor if you’ve had any history of ailments in the past or present such as kidney disease, liver problems, gallbladder disease or if you have trouble with alcohol use, etc. The medicine might inadvertently provoke or interfere with these already existing problems, so clear out your history before stating fenofibrate’s course.