Allopurinol Side Effects, Upsides, Downsides, Tips

Allopurinol is an externally administered medicine. It is sold under numerous brand names with Zyloric and Zyloprim being the most common ones.


Allopurinol is used to treat high levels of uric acid in the bloodstream. It works by reducing the amount of uric acid present, and hence, serves as a means of treatment and prevention of conditions like gout and kidney stones. It is also given to patients receiving cancer chemotherapy treatment as they have high levels of uric acid.


Side effects of Allopurinol:

Allopurinol, just like other medications, comes with some side effects. These side effects range from mild to severe and must be reported instantly.

Some of the common side effects that are considered to be mild in nature are as follows:

  • Vomiting
  • Diarrhea
  • Headaches
  • Feeling drowsy
  • Pain in muscles
  • Altered sense of tasting

Most of the times, these side effects tend to occur at the start of the treatment. They usually perish within a day or two as it does not take long for the body to adjust and get accustomed to the presence of the medicine. However, they may persist and start to worsen, triggering serious medical conditions. Therefore, seek medical help promptly if any side effect is experienced.


Some of the potential side effects it is known to cause include:

  • Fever accompanied by a sore throat
  • Headaches
  • Signs of a severe allergic reaction; severe blistering, peeling, and red skin rash
  • Pain during urination
  • Blood in urine
  • Upper stomach pain
  • Loss of appetite with weight loss
  • Clay-colored stools
  • Jaundice
  • Urinating less than usual
  • Pain in the joints
  • Severe tingling, and/or numbness
  • Extreme muscle weakness
  • Easy bruising
  • Unusual bleeding through the nose, mouth, rectum or vagina.
  • Purplish red pinpoint spots under your skin.

Note that other side effects not listed in this guide may also be experienced. Usually, doctors and/or pharmacists inform the patients about the side effects they are likely to experience at the start of their treatment.

For further queries and concerns regarding this, a doctor and/or a pharmacist may be consulted.


How to use?

Before starting, you are strongly advised to go through the direction given on the prescription label.

The medicine is administered both orally and intravenously. Usually, it is advised to be taken once a day. However, your doctor may advise you otherwise. Follow your doctor’s instructions regarding this. Take timely and balanced doses. Take the medicine after a meal.

Do not take huge amounts of ascorbic acid, i.e., Vitamin C while taking this medication.


  • Neither use nor prescribe it to someone without the recommendation of a doctor.
  • It may interact negatively with certain medicines. Thus, give names of all the medicines, if any, that you use to your doctor as a safety measure.
  • It is not prescribed under certain medical terms. Thus, provide your doctor with your medical history to avoid any inconvenience.


  • Inform your doctor immediately if you become pregnant.
  • It can pass through the breast milk and possibly harm your baby. Thus, let your doctor know if you breastfeed a baby.
  • Keep it away from children’s reach, moisture, and heat.