Trazodone Side Effects, How it Works, Upsides & Downsides

Trazodone is a well-known antidepressant medicine which is prescribed for various depressive disorders, anxiety issues and other complications such as alcohol dependence.  It helps in improving your mood, appetite and energy levels and allows you to sleep faster. It is suggested that Trazodone works by restoring the balance of Serotonin in the brain.


Serotonin is a natural chemical in your brain which has a dominant influence on your mood and emotions. The active ingredient in this medicine is trazodone hydrochloride and coupled with inactive ingredients such as yellow ferric oxide, magnetism stearate, and sodium starch glycolate. Trazodone may be used for other conditions not mentioned in this medication guide.

SIDE EFFECTS:         

Trazodone, like any medicinal drug, has some side effects which can be expected as your body adjusts to the new drugs in the system. A few of the common side effects which you are most likely to experience are listed below. Inform your doctor if they continue over a prolonged period and become severe:

  • Dizziness
  • Confusion
  • Blurred vision
  • Faintness
  • Problems with muscle control or coordination
  • Lightheadedness
  • Sweating
  • Numbness
  • Decreased concentration
  • Slurred speech
  • Headaches
  • Shortness of breath
  • Slow heartbeat
  • Dry mouth
  • Trouble with remembering
  • Unpleasant taste


Severe Side Effects:

If you go through any of the following or they become increasingly stringent, see your doctor immediately:

  • Change in sexual ability
  • Hallucinations
  • Restlessness
  • Tremors
  • Nightmares
  • Ringing in the ears
  • Yellowing of eyes and/or skin
  • Severe allergic reactions
  • Problems urinating
  • Irregular heartbeat
  • Blood in urine
  • Seizures
  • Blurred vision, swelling and widened pupils.
  • Severe dizziness and trouble breathing



Trazodone must be taken orally, with or without food. It is strongly instructed that you follow the dosage that your doctor prescribes; considering your medical conditions, age, weight and therapeutic response. Usually, it is directed that you take it once in the morning.

To avoid injuries related to dizziness, take your first dose at bedtime unless prescribed otherwise. The dosage will be lower at the start, and then will be gradually increased. If you miss a dose, you may have to restart with a lower dose. Consult your specialist about any such issues.

For Trazodone to work efficiently, you are advised to not abruptly discontinue the course or extend it, as side effects such as anxiety. Agitation and trouble sleeping can occur.

Alternatively, it may take 2-4 weeks before you experience full effects.




Before you start your prescribed dosage, inform your doctor about your medical history, specifically highlight any condition or history of mental disorders, suicidal tendencies, and substance abuse. You must discuss with your doctor if you have any of the following medical conditions or their history:

  • Heart diseases such as cardiac arrests.
  • Blood pressure problems
  • Mental/mood disorders such as depression, psychosis
  • Suicidal tendencies
  • Liver or kidney diseases
  • Glaucoma

It is also cautioned that Trazodone may cause dizziness and drowsiness. If you take alcoholic drinks or recreational drugs such as marijuana; the dizziness can get severe coupled with this drug. It is advised that you stop drinking or any activity that requires you to be alert; to prevent any mishaps.



It is also instructed that you inform your doctor if you are taking any medicines beforehand, prescribed or not in nature and herbal drugs. According to which, your doctor will give you the precise prescription and dosage that suits your medical condition.

Elder individuals are prone to be more sensitive to the above-mentioned side effects, specifically dizziness and low blood pressure. They feel exceptionally dizzy when getting up from a lying or sitting position.



The risk of QT prolongation may arise if you have certain medical conditions or are prescribed drugs that may encourage QT prolongation. Inform your doctor if you have heart complications, slow heartbeat, QT prolongation or a history of sudden cardiac death in your family.

This medicine is not recommended in the case of pregnancy; it is advised that Trazodone only is taken if extremely necessary; this drug is also known to pass into breast milk and cause undesirable effects. Consult your doctor about your medical conditions and risk associated with them.