Spironolactone Side Effects, How it Works, Upsides & Tips

The potassium-sparing diuretic water oil, spironolactone, is a drug that stops the body from accumulating too much salt and keeps one’s potassium levels from getting too low. Heart failure, high blood pressure or hypokalemia can be treated by spironolactone. People who have congestive heart failure, cirrhosis of the liver, or a kidney disorder called nephrotic syndrome, and have fluid retention can be treated by spironolactone.


The adrenal glands make aldosterone which is a hormone which helps control the salt and water balance in one’s body. Spironolactone can be used to treat a condition in which one has too much aldosterone.


Side effects

Even though it is rare but one should seek emergency medical help immediately if any allergic reactions from spironolactone occur. The doctor has prescribed this medication because they have judged that the benefit that the medication contains is greater than the risk of side effects. However, if the following symptoms of serious reactions occur one should seek medical assistance immediately:

  • Rash
  • Itching/ swelling (including the face/ tongue/ throat)
  • Severe dizziness
  • Difficulty in breathing


The following are some of the side effects which are common and can be reduced by the intake of a low dosage:

  • Mild nausea or vomiting
  • Diarrhea;
  • Breast swelling or tenderness;
  • Dizziness
  • Headache
  • Mild drowsiness;
  • Leg cramps
  • Impotence, difficulty having an erection

However, one should promptly contact a doctor or a healthcare specialist if the less occurring yet/ or more serious side effects occur:

  • Low amount of magnesium in the blood
  • Low amount of sodium in the blood
  • Dizzy
  • Enlarged breasts
  • Head pain
  • Inability to have an erection
  • Sexual problems
  • Abnormally low blood pressure
  • Acid-base problem with low chloride and basic PH in blood
  • Allergic reaction causing inflammation of blood vessels
  • Bleeding of the stomach or intestines
  • Decreased blood platelets
  • Decreased blood volume
  • Dress syndrome
  • Extreme loss of body water
  • High amount of uric acid in the blood
  • High blood sugar
  • Increased eosinophils in the blood
  • Inflammation of the liver with stoppage of bile flow
  • Kidney disease with a reduction in kidney function
  • Life-threatening allergic reaction
  • Low amount of calcium in the blood


  • Stevens-Johnson syndrome
  • Stomach ulcer
  • Toxic epidermal necrolysis
  • Trouble breathing
  • Vasculitis
  • The absence of menstrual periods
  • Altered interest in having sexual intercourse
  • Bleeding after menopause
  • Breast tenderness
  • Burning stomach
  • Confused
  • Diarrhea
  • Drowsiness
  • Feel like throwing up
  • Fever
  • Hair loss
  • Inflammation of skin caused by an allergy
  • Irregular periods
  • Itching
  • Leg cramps
  • Problem with periods
  • Sluggishness
  • Stomach cramps
  • Throwing up
  • Uncoordinated



How to Use

The medication needs to be taken by mouth as instructed by one’s doctor. One should take it with food or milk if stomach pain occurs. It is recommended to take the medication early morning in order to stop having to get up at night for urinating. If one is using the liquid form of the medication, the bottle needs to be shaken well before use. One should use a special measuring device/spoon in order to measure the dose. The liquid form can also be taken with or without food. Take this medication regularly in order to get the most benefit from it. Dosage is based on your medical condition and response to therapy, and the dosage is based on body weight in children.



  • The first precaution to take is to consult the doctor and tell him whether you have any allergies either to the medication or any of the ingredients in spironolactone tablets or any other allergies.
  • A medical history report should be given to the doctor or healthcare specialist especially of kidney problems, liver problems, untreated mineral imbalance, decreased adrenal gland function


  • One should limit foods with high potassium since spironolactone increases one’s potassium levels
  • Since this drug makes one dizzy or drowsy or blurs the vision, the intake of alcohol or marijuana may worsen it. Thus, one should not drive, use machinery, or do anything that needs alertness or clear vision until one can do it safely.